Measurement of purine release with microelectrode biosensors
نویسندگان
چکیده
منابع مشابه
Biosensors for ATP and adenosine: new insights from real-time measurement of purine release
In addition to its central role in cellular biochemistry, ATP acts as a neurotransmitter and neuromodulator in the nervous system. ATP is particularly important as a neurotransmitter in sensory pathways and can act as a co-transmitter with many other neurotransmitters such as acetylcholine, noradrenaline, GABA and glutamate. ATP is also used by glial cells communicate with other glial cells and...
متن کاملImplantable microelectrode biosensors for neurochemical monitoring of brain functioning
Identification, monitoring and quantification of biomolecules in the CNS is a field of growing interest for identifying biomarkers of neurological diseases. Implantable enzymatic microelectrode biosensors are a unique minimally invasive tool for real-time monitoring. Progress in microfabrication technologies has opened new possibilities in the preparation of complex biosensor architectures with...
متن کاملPolycrystalline-Diamond MEMS Biosensors Including Neural Microelectrode-Arrays
Diamond is a material of interest due to its unique combination of properties, including its chemical inertness and biocompatibility. Polycrystalline diamond (poly-C) has been used in experimental biosensors that utilize electrochemical methods and antigen-antibody binding for the detection of biological molecules. Boron-doped poly-C electrodes have been found to be very advantageous for electr...
متن کاملDetection of endogenous substances with enzymatic microelectrode biosensors in the kidney.
Direct real-time measurements of purinergic agents and reactive oxygen species concentrations have been of great value in understanding the functional roles of these substances in a number of diseases including chronic kidney disease and hypertension. The interstitial concentrations of these intermediate signaling molecules and dynamics of their release are important autocrine and paracrine fac...
متن کاملModeling microelectrode biosensors: free-flow calibration can substantially underestimate tissue concentrations
Microelectrode amperometric biosensors are widely used to measure concentrations of analytes in solution and tissue including acetylcholine, adenosine, glucose, and glutamate. A great deal of experimental and modeling effort has been directed at quantifying the response of the biosensors themselves; however, the influence that the macroscopic tissue environment has on biosensor response has not...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2011
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-011-9273-4